| 1368 | Jan 23. Zhu Yuanzhang, founder of the Ming Dynasty, captures the city of Nanjing and declares himself emperor. |
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| 1381 | Zhu Di, fourth son of Zhu Yuanzhang, begins a rebellion against his nephew Emperor Jianwen. |
| 1399 | Jan 2. Zhu Di captures Nanjing and proclaims himself emperor, taking the name Yongle. |
| 1402 | Yongle moves the capital of China from Nanjing to Beijing. |
| 1420 | Sep 28. The Forbidden City is completed in Beijing, serving as the imperial palace for the Ming emperors. |
| 1433 | Jul 11. The Treasure Fleet voyages, led by Admiral Zheng He, reach the east coast of Africa. |
| 1449 | Jul 15. The Ming Dynasty defeats the Mongol-led Northern Yuan Dynasty, establishing control over all of China. |
| 1464 | May 11. The Zhengtong Emperor is captured by the Mongols and replaced by his younger brother, who becomes known as the Jingtai Emperor. |
| 1487 | Jan 28. The Jiajing Emperor ascends to the throne. |
| 1521 | Mar 16. Portuguese explorer Ferdinand Magellan reaches the Philippines, beginning European contact with Southeast Asia. |
| 1550 | Jun 14. The Wanli Emperor ascends to the throne. |
| 1572 | Jul 28. The Wanli Emperor moves the capital from Nanjing to the new city of Beijing. |
| 1644 | Apr 25. Beijing falls to the Manchu forces of the Qing Dynasty, ending the Ming Dynasty. |